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Therapeutic applications of quadruplex nucleic acids / Stephen Neidle.

By: Material type: TextTextLanguage: English Publication details: London ; Waltham, MA : Elsevier/Academic Press, 2012.Edition: 1st edDescription: xii, 196 p. : ill. ; 24 cmISBN:
  • 9780123751386 (hbk)
  • 0123751381 (hbk)
Subject(s): DDC classification:
  • 615.36 NEI 2012 23
LOC classification:
  • RM666.N87 N45 2012
NLM classification:
  • QU 58
Contents:
Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures.
Summary: "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.
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Item type Current library Call number Status Date due Barcode
Sách, chuyên khảo, tuyển tập Phòng DVTT KHTN & XHNV Kho tài liệu chiến lược 615.36 NEI 2012 (Browse shelf(Opens below)) Available 01071000806

Includes bibliographical references and index.

Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures.

"Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover.

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