TY  - BOOK
AU  - Neidle,Stephen
TI  - Therapeutic applications of quadruplex nucleic acids
SN  - 9780123751386 (hbk)
AV  - RM666.N87 N45 2012
U1  - 615.36 23
PY  - 2012///
CY  - London, Waltham, MA
PB  - Elsevier/Academic Press
KW  - Quadruplex nucleic acids
KW  - Therapeutic use
KW  - G-Quadruplexes
KW  - Antineoplastic Agents
KW  - therapeutic use
KW  - pharmacology
KW  - Neoplasms
KW  - drug therapy
KW  - Nucleic Acid Conformation
KW  - Telomere
KW  - chemistry
KW  - Điều trị học
KW  - Dược lý học
KW  - Axit nucleic
N1  - Includes bibliographical references and index; Introduction: quadruplexes and their biology -- DNA and RNA quadruplex structures -- The structures of human telomeric DNA quadruplexes -- Telomeric quadruplex ligands I: anthraquinones and acridines -- Telomeric quadruplex ligands II: polycyclic and non-fused ring compounds -- The biology and pharmacology of telomeric quadruplex ligands -- Genomic quadruplexes as therapeutic targets -- RNA quadruplexes -- Design principles for quadruplex-binding small molecules -- The determination of quadruplex structures
N2  - "Therapeutic applications of quadruplex nucleic acids provides a single comprehensive survey that describes and assesses recent advances in quadruplex therapeutics and targeting strategies. It also covers the underlying fundamentals of such topics as quadruplex structure, small-molecule recognition, biological roles of genomic quadruplexes, and quadruplex informatics"--P. [4] of cover
ER  -